Fast, heart-rate independent, whole-heart, free-breathing, three-dimensional myocardial BOLD MRI at 3T with simultaneous 13N-ammonia PET validation in canines
نویسندگان
چکیده
Background Myocardial BOLD MRI is a non-contrast approach for examining myocardial perfusion. Although recent developments have shown promising technical advancements, current myocardial BOLD MR methods are still limited by: (a) poor spatial coverage; (b) imaging confounders; and (c) imaging artifacts, particularly at 3T. To address these limitations, we developed a heart-rate independent, free-breathing 3D T2 mapping technique at 3T that utilizes near 100% imaging efficiency, which can be completed within 3 minutes. We tested our method in a canine model and validated our findings with simultaneously acquired N-ammonia PET perfusion data in a whole-body PET/MR system.
منابع مشابه
Whole-heart, free-breathing, three-dimensional myocardial BOLD MRI at 3T with simultaneous 13N-ammonia PET in canines
Background Myocardial BOLD MRI is an emerging non-contrast approach for the assessment of ischemic heart disease. However, current BOLD CMR methods (T2-weighted, T2*-weighted or bSSFP) are limited by poor spatial coverage and image artifacts (e.g. coil bias, B1 and B0 inhomogeneities). To address these limitations, we developed a fast, free breathing 3D T2 mapping technique at 3T that utilizes ...
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